Source: Scientific Briefing
Auto Added by WPeMatico
Source: Scientific Briefing
“The 15 m high visitor’s tower provides you with a 360-degree view from the tower of Dresden’s Town Hall and reveals the extent of the destruction in the panorama by Yadegar Asisi, almost 3,000 m² in size.”
Image: YouTube screengrab
CRISPR-Cas9 is the cutting-edge genomic technology that essentially lets you target exact sequences in DNA and then cut into them like a knife and insert or remove a gene. You may remember it from that Chinese scientist who successfully (but controversially) implanted gene-edited embryos into a woman who then gave birth to live lab babies. More often, it’s used to create things like malaria-resistant mosquitoes or mushrooms that don’t brown as fast.
But it does have a lot of practical medical potential, too. It’s already been used to remove HIV from a patient’s genome. And now, after CRISPRing out a blindness-causing gene from mice, scientists have now successfully scaled-up this procedure to work in a live human body. From NPR:
In this new experiment, doctors at the Casey Eye Institute in Portland, Ore., injected (into the eye of a patient who is nearly blind from a condition called Leber congenital amaurosis) microscopic droplets carrying a harmless virus that had been engineered to deliver the instructions to manufacture the CRISPR gene-editing machinery.
The goal is that once the virus carrying the CRISPR instructions has been infused into the eye, the gene-editing tool will slice out the genetic defect that caused the blindness. That would, the researchers hope, restore production of a crucial protein and prevent the death of cells in the retina, as well as revive other cells — enabling patients to regain at least some vision.
The procedure, which takes about an hour to perform, involves making tiny incisions that enable access to the back of the eye. That allows a surgeon to inject three droplets of fluid containing billions of copies of the virus that has been engineered to carry the CRISPR gene-editing instructions under the retina.
Essentially, this means they’re using the CRISP technology to remove the one mutated gene in the person’s DNA that is responsible for the defect that causes this specific kind of blindness. While it’s too early to know if it actually worked — the human body will still need some time to re-map itself and adjust to its new genes — but the potential to make these kinds of changes in live human bodies is huge.
Image: Public Domain
From the Dungeon Masters Guild:
Eat the Rich is a collection of explicitly anticapitalist adventures for the Dungeons & Dragons roleplaying game. Each original adventure dives into classic D&D tropes, and puts a new spin on them. Tackling issues of workers’ rights, health care, the prison industrial complex, the environment, animal rights, agriculture and more, these adventures will make you passionate to join the revolution.
Eat the Rich features 17 original adventures for tiers 1-4, in a 213 page colour PDF. Set in the Forgotten Realms, Ravnica, Eberron, or ready to be dropped into your own setting, the anthology features work by a global team of new and established designers and artists.
If you want to free the Goblins from the bonds of racial oppression and forge your dwarves together in an iron working union to face down the tyrannical production expectations of the rock giants, now’s your chance.
Eat the Rich, Volume 1 [Dungeon Masters Guild]
Image: Huntleigh / Wikimedia Commons (CC 3.0)
Just because you can do a thing, doesn’t mean you should. This rule especially holds true where the removal of radiation safeguards are involved.
There is absolutely nothing in this trailer that doesn’t instill me with an intense sense of glee.
The tiny skull, about the size of a thumbnail, trapped in amber may belong to the smallest dinosaur scientists have ever discovered. Paleontologist Lida Xing of the China University of Geosciences spotted the skull in a 99-million-year-old chunk of amber from northern Myanmar. From the New York Times:
[Xing, Chinese Academy of Sciences paleontologist Jingmai O’Connor, and their colleagues] called the bird Oculudentavis khaungraae — a name that comes from the Latin words for eye, teeth and bird. The dinosaur’s skull is only 14.25 millimeters, or a little more than half an inch, from its beak to the end of its skull. The animal had bulbous eyes that looked out from the sides of its head, rather than straight ahead like the eyes of an owl or a human.
“We were able to show that this skull is even smaller than that of a bee hummingbird, which is the smallest dinosaur of all time — also the smallest bird,” O’Connor said. “This is a tiny skull, and it’s just preserved absolutely pristinely”….
Most scientists now believe that birds are theropods, dinosaurs of a group that included tyrannosaurus and spinosaurus, but that birds were on their own evolutionary branch from a common ancestor. Paleontologists have long assumed that as birds evolved away from other dinosaurs, having teeth was a trait that was in the process of disappearing altogether. “But this specimen strongly shows that evolution’s really going in all different directions,” Dr. O’Connor said.
More at Nature: “Tiny bird fossil might be the world’s smallest dinosaur”
image: Lida Xing
This is the way to get a Baby Yoda minifig.
The 1000+ piece LEGO Razor Crest can be ordered in advance of its September debut.
“There are bugs and they will bite on your face.” — a bad review about Sequoia National Park
This is hilarious. Designer Amber Share discovered that there were one-star reviews for all 62 of our National Parks and decided to illustrate and hand letter travel posters for them “as a way to put a positive, fun spin on such a negative mindset.” She calls her Subpar Parks series a “snarky love letter to the National Parks System” and it’s absolutely delightful.
If you would just pave all of the hiking trails, we wouldn’t have this problem, @cuyahogavalleynps. . . . . #cuyahogavalleynationalpark #naturalohio #goparks #weareparks #nationalparkgeek @nationalparkservice #nationalparksusa #illustrationnow #passiontopaid #passiontopaid2019 #usnationalparks
A post shared by Subpar Parks (@subparparks) on Feb 26, 2020 at 7:31am PST
Call me McKayla Maroney because I am unimpressed, @grandcanyonnps. #handlettering #handlettering #illustration #handdrawntype #passiontopaid #passiontopaid2019 #nationalparks #grandcanyon @nationalparkservice
A post shared by Subpar Parks (@subparparks) on Dec 18, 2019 at 6:44am PST
images via Amber Share, used with permission