— いけさん ィェィㇴ太郎 (@is_ikesan) May 4, 2020
Category: 01 Main
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Wow. Voice actor Dee Bradley Baker is an incredibly talented man.
We are about to take you on an audio odyssey unlike any other. It’s kind of like ASMR for people who find the sounds of squealing pigs, angry squirrels and raging dinosaurs soothing. And it’s all from the mouth of Dee Bradley Baker, one of Hollywood’s top voice actors. Baker specializes in creatures and animals, and you know his voice. You’ve heard him as Perry the Platypus on “Phineas and Ferb,” Klaus the Fish on “American Dad” and Daffy Duck in “Space Jam.” A vocal genius, Baker invites us into his recording studio, where he improvises a series of sounds.
screengrab via Great Big Story
I’m not usually a fan of furniture that converts from one thing into another, because it’s usually better to just use the two different things you need rather than have to deal with one crappy transformer. But this wall shelf that converts into a desk looks pretty good!
Source: Wall shelf converts into desk
As Bruce Sterling says, “Impressive accuracy by whoever that is.”
“The 15 m high visitor’s tower provides you with a 360-degree view from the tower of Dresden’s Town Hall and reveals the extent of the destruction in the panorama by Yadegar Asisi, almost 3,000 m² in size.”
Image: YouTube screengrab
CRISPR-Cas9 is the cutting-edge genomic technology that essentially lets you target exact sequences in DNA and then cut into them like a knife and insert or remove a gene. You may remember it from that Chinese scientist who successfully (but controversially) implanted gene-edited embryos into a woman who then gave birth to live lab babies. More often, it’s used to create things like malaria-resistant mosquitoes or mushrooms that don’t brown as fast.
But it does have a lot of practical medical potential, too. It’s already been used to remove HIV from a patient’s genome. And now, after CRISPRing out a blindness-causing gene from mice, scientists have now successfully scaled-up this procedure to work in a live human body. From NPR:
In this new experiment, doctors at the Casey Eye Institute in Portland, Ore., injected (into the eye of a patient who is nearly blind from a condition called Leber congenital amaurosis) microscopic droplets carrying a harmless virus that had been engineered to deliver the instructions to manufacture the CRISPR gene-editing machinery.
The goal is that once the virus carrying the CRISPR instructions has been infused into the eye, the gene-editing tool will slice out the genetic defect that caused the blindness. That would, the researchers hope, restore production of a crucial protein and prevent the death of cells in the retina, as well as revive other cells — enabling patients to regain at least some vision.
The procedure, which takes about an hour to perform, involves making tiny incisions that enable access to the back of the eye. That allows a surgeon to inject three droplets of fluid containing billions of copies of the virus that has been engineered to carry the CRISPR gene-editing instructions under the retina.
Essentially, this means they’re using the CRISP technology to remove the one mutated gene in the person’s DNA that is responsible for the defect that causes this specific kind of blindness. While it’s too early to know if it actually worked — the human body will still need some time to re-map itself and adjust to its new genes — but the potential to make these kinds of changes in live human bodies is huge.
Image: Public Domain
From the Dungeon Masters Guild:
Eat the Rich is a collection of explicitly anticapitalist adventures for the Dungeons & Dragons roleplaying game. Each original adventure dives into classic D&D tropes, and puts a new spin on them. Tackling issues of workers’ rights, health care, the prison industrial complex, the environment, animal rights, agriculture and more, these adventures will make you passionate to join the revolution.
Eat the Rich features 17 original adventures for tiers 1-4, in a 213 page colour PDF. Set in the Forgotten Realms, Ravnica, Eberron, or ready to be dropped into your own setting, the anthology features work by a global team of new and established designers and artists.
If you want to free the Goblins from the bonds of racial oppression and forge your dwarves together in an iron working union to face down the tyrannical production expectations of the rock giants, now’s your chance.
Eat the Rich, Volume 1 [Dungeon Masters Guild]
Image: Huntleigh / Wikimedia Commons (CC 3.0)
Just because you can do a thing, doesn’t mean you should. This rule especially holds true where the removal of radiation safeguards are involved.
There is absolutely nothing in this trailer that doesn’t instill me with an intense sense of glee.