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Moist

“Ugh, God, could you not say that?”

Enjoy this irriguous parody of Terence Malick, Christopher Nolan, etc., written and directed by Eli & Andrew Rousso.


Source: Moist

How to diversify your workplace when you’re stuck working at home

My friends John J. King and Ramona Rose King have spent their quarantine creating a new weekly web series called Home Office. Riffing on the confessional style of the original Office, each 5-ish-minute episode details the trials and tribulations of a newly married couple trying to learn how to turn their tiny apartment into a shared office space (While John and Ramona are both playing caricatures of themselves, I  personally feel it’s a little too-close to my own life). Even the Boston Globe has celebrated its delightfulness.

In the episode above, the Kings tackle the very important topic of workplace diversity. Maybe their experience can help you bring some new perspectives to your own home office.

With Home Office, a Boston couple concocts a workplace comedy from their tiny apartment [Terry Byrne / The Boston Globe]


Source: How to diversify your workplace when you’re stuck working at home

The sexy medical researcher in this bestselling 1991 romance novel was based on Anthony Fauci

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Journalist and novelist Sally Quinn’s bestselling 1991 novel of romance and intrigue, Happy Endings, is about fictional presidential widow Sadie Grey who falls for a sexy medical researcher working for the National Institutes of Health on a new AIDS treatment. Yes, the alluring government scientist with the “low, melodious, sexy, almost hypnotic” voice, as Quinn described the character, is none other than Dr. Anthony Fauci. From Benjamin Wofford’s article in Washingtonian:

Part searing romance, part roman à clef, “Happy Endings” made the bestseller list during a year when HIV-related deaths were then the highest ever recorded in the United States. By then, Fauci was the government scientist best known for combatting the virus’s spread as director of the National Institute of Allergy and Infectious Diseases.

It was around this time that Quinn first encountered the real-life Fauci, at a Washington function where the two were paired as dinner partners. With his tie askew and from behind enormous glasses, Fauci left an impression of earnest brilliance, enough to inspire the main character of Quinn’s upcoming novel.

“I just fell in love with him,” Quinn told me recently, recalling their evening together. “Usually those dinners, you make polite conversation, and that’s it. But we had this intense conversation, personal conversation. I though, ‘Wow, this guy is amazing.’”

[…]

“He was so different from most Washington people, because he’s so self-effacing. He’s not in it for the glory or the name recognition,” Quinn recalled. She decided to have Grey “fall in love with this doctor who does this amazing work, and doesn’t get a lot of publicity.”

Sally Quinn Modeled the Erotic Hero of Her 1991 Bestseller on…Anthony Fauci(Washingtonian)


Source: The sexy medical researcher in this bestselling 1991 romance novel was based on Anthony Fauci

Voice actor shows off his skills by mimicking animal sounds

Wow. Voice actor Dee Bradley Baker is an incredibly talented man.

Great Big Story:

We are about to take you on an audio odyssey unlike any other. It’s kind of like ASMR for people who find the sounds of squealing pigs, angry squirrels and raging dinosaurs soothing. And it’s all from the mouth of Dee Bradley Baker, one of Hollywood’s top voice actors. Baker specializes in creatures and animals, and you know his voice. You’ve heard him as Perry the Platypus on “Phineas and Ferb,” Klaus the Fish on “American Dad” and Daffy Duck in “Space Jam.” A vocal genius, Baker invites us into his recording studio, where he improvises a series of sounds.

screengrab via Great Big Story


Source: Voice actor shows off his skills by mimicking animal sounds

The Dresden Panometer gives visitors an immersive experience on a 1:1 scale of the Allied bombing raids of 1945

The Dresden Panometer is a converted former gasometer that exhibits 360°  panoramas created by the artist Yadegar Asisi.

“The 15 m high visitor’s tower provides you with a 360-degree view from the tower of Dresden’s Town Hall and reveals the extent of the destruction in the panorama by Yadegar Asisi, almost 3,000 m² in size.”

Image: YouTube screengrab


Source: The Dresden Panometer gives visitors an immersive experience on a 1:1 scale of the Allied bombing raids of 1945

Scientists have successfully performed CRISPR gene editing in a live human body for the first time ever

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CRISPR-Cas9 is the cutting-edge genomic technology that essentially lets you target exact sequences in DNA and then cut into them like a knife and insert or remove a gene. You may remember it from that Chinese scientist who successfully (but controversially) implanted gene-edited embryos into a woman who then gave birth to live lab babies. More often, it’s used to create things like malaria-resistant mosquitoes or mushrooms that don’t brown as fast.

But it does have a lot of practical medical potential, too. It’s already been used to remove HIV from a patient’s genome. And now, after CRISPRing out a blindness-causing gene from mice, scientists have now successfully scaled-up this procedure to work in a live human body. From NPR:

In this new experiment, doctors at the Casey Eye Institute in Portland, Ore., injected (into the eye of a patient who is nearly blind from a condition called Leber congenital amaurosis) microscopic droplets carrying a harmless virus that had been engineered to deliver the instructions to manufacture the CRISPR gene-editing machinery.

[…]

The goal is that once the virus carrying the CRISPR instructions has been infused into the eye, the gene-editing tool will slice out the genetic defect that caused the blindness. That would, the researchers hope, restore production of a crucial protein and prevent the death of cells in the retina, as well as revive other cells — enabling patients to regain at least some vision.

[…]

The procedure, which takes about an hour to perform, involves making tiny incisions that enable access to the back of the eye. That allows a surgeon to inject three droplets of fluid containing billions of copies of the virus that has been engineered to carry the CRISPR gene-editing instructions under the retina.

Essentially, this means they’re using the CRISP technology to remove the one mutated gene in the person’s DNA that is responsible for the defect that causes this specific kind of blindness. While it’s too early to know if it actually worked — the human body will still need some time to re-map itself and adjust to its new genes — but the potential to make these kinds of changes in live human bodies is huge.

In A 1st, Scientists Use Revolutionary Gene-Editing Tool To Edit Inside A Patient [Rob Stein / NPR]

Image: Public Domain


Source: Scientists have successfully performed CRISPR gene editing in a live human body for the first time ever